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Screen scene
In contrast to target-based strategies, phenotypic drug discovery does not rely on knowledge of a specific drug target or a hypothesis...
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It's been a hard day's development
Pharma small molecule discovery has continued its longtime inexorable decline noted some time ago in this paper. There is little doubt...
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Prediction looks to the future
It’s long been known that better early prediction of drug-like compound properties overcomes costly drug attrition later. But prediction...
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Thymus up: the hidden powers of HCAC7
Some autoimmune diseases, like lupus, affect multiple tissues, but some, like inflammatory bowel disease, affect only specific types. A...
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Reducing safety-related drug attrition . . . the old-fashioned way
Everyone knows that off-targets are the bane of a drug developers existence, but surprisingly little has been done to address the...
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Finally getting a handle on rare variations
Rare variations in genomic data have long been the bugaboo of computational biologists, those soldiers at the forefront of personalized...
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Scratch + sniffles
The overlap between seasonal allergies, asthma and eczema has long been recognized. All three are treated by antihistamines, for example,...
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