Alzheimer’s Disease is an asteroid headed directly at Earth. An astonishing 1 in 4 Americans are expected to develop this devastating...

It seems like an obvious concept: Let's say you are developing a drug that works by inhibiting, say, phosphodiesterase-4 (PDE-4) to treat...

The holy grail of the pharma industry is FDA approval, but the final clue may be positive top-line (Phase III) results. However, it is...

High-throughput screening (HTS) has been a blessing and a curse. A blessing in codifying a straightforward approach to discovering drug...

Where to even begin? A mold flew in through the window and, presto, penicillin. Hey, then, why not screen all the compounds we have on...

We waited a long time for a real gene therapy, though we were promised it would be easy. So now we are feeling optimistic about the other...

The story begins in the 1950s when thalidomide was approved as an over the counter sedative in Europe, but conspicuously rejected by the...

Small molecule chemical antibiotics are among the most prescribed drugs in the world, and few individuals in the first world can say they...

Martin Karplus of Harvard, Michael Levitt of Stanford and Arieh Warshel of USC were awarded the Nobel Prize in Chemistry in 2013 for...

Clinical holds are lost battles in the war against drug attrition. The process of drug development critically revolves around the FDA’s...